The Meningioma Research Group is interested in all aspects of clinical research related to meningioma. Current research themes include:

• Outcome Assessment following meningioma resection
• Natural History of Meningioma Growth
• Novel Imaging Methods for Pre-operative planning

 

Group Leaders:

Mr Thomas Santarius Consultant Neurosurgeon

Mr Ramez Kirollos Senior Consultant Neurosurgeon, National Neuroscience Institute, Singapore

Mr Adel Helmy University Associate Professor & Hon Consultant Neurosurgeon Email: aeh33@cam.ac.uk

Members:

Mr Mutwakil Abdulla

Clinical Trials:

Surgeons Trial Of Prophylaxis for Epilepsy in seizure naïve patients with Meningioma: a randomised controlled trial (STOP’EM)

Key Publications

1. Results of Transcranial Resection of Olfactory Groove Meningiomas in Relation to Imaging-Based Case Selection Criteria for the Endoscopic Approach.
   Patel K, Kolias AG, Santarius T, Mannion RJ, Kirollos RW. Oper Neurosurg (Hagerstown). 2019 May 1;16(5):539-548.
2. An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures.
   Collord G, Tarpey P, Kurbatova N, Martincorena I, Moran S, Castro M, Nagy T, Bignell G, Maura F, Young MD, Berna J, Tubio JMC, McMurran CE, Young AMH, Sanders M, Noorani I, Price SJ, Watts C, Leipnitz E, Kirsch M, Schackert G, Pearson D, Devadass A, Ram Z, Collins VP, Allinson K, Jenkinson MD, Zakaria R, Syed K, Hanemann CO, Dunn J, McDermott MW, Kirollos RW, Vassiliou GS, Esteller M, Behjati S, Brazma A, Santarius T, McDermott U.Sci Rep. 2018 Sep 10;8(1):13537. doi: 10.1038/s41598-018-31659-0.
3. Predictors of early progression of surgically treated atypical meningiomas.
   Budohoski KP, Clerkin J, Millward CP, O’Halloran PJ, Waqar M, Looby S, Young AMH, Guilfoyle MR, Fitzroll D, Devadass A, Allinson K, Farrell M, Javadpour M, Jenkinson MD, Santarius T, Kirollos RW.Acta Neurochir (Wien). 2018 Sep;160(9):1813-1822. doi: 10.1007/s00701-018-3593-x. Epub 2018 Jun 30.
4. Correlation of volumetric growth and histological grade in 50 meningiomas.
   Soon WC, Fountain DM, Koczyk K, Abdulla M, Giri S, Allinson K, Matys T, Guilfoyle MR, Kirollos RW,Santarius T.Acta Neurochir (Wien). 2017 Nov;159(11):2169-2177. doi: 10.1007/s00701-017-3277-y. Epub 2017 Aug 9.
5. Volumetric growth rates of meningioma and its correlation with histological diagnosis and clinical outcome: a systematic review.
   Fountain DM, Soon WC, Matys T, Guilfoyle MR, Kirollos R, Santarius T.Acta Neurochir (Wien). 2017 Mar;159(3):435-445. doi: 10.1007/s00701-016-3071-2. Epub 2017 Jan 18.
6. A quest towards personalised medicine for grade II meningiomas–will need to zoom in.
   Santarius T, Jenkinson MD, Kirollos RW.Acta Neurochir (Wien). 2016 May;158(5):931-2.
7. Image-guided resection of spheno-orbital skull-base meningiomas with predominant intraosseous component.
   Marcus H, Schwindack C, Santarius T, Mannion R, Kirollos R.Acta Neurochir (Wien). 2013 Jun;155(6):981-8. doi: 10.1007/s00701-013-1662-8. Epub 2013 Mar 10.
8. Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations.
   Reuss DE, Piro RM, Jones DT, Simon M, Ketter R, Kool M, Becker A, Sahm F, Pusch S, Meyer J, Hagenlocher C, Schweizer L, Capper D, Kickingereder P, Mucha J, Koelsche C, Jäger N, Santarius T, Tarpey PS, Stephens PJ, Andrew Futreal P, Wellenreuther R, Kraus J, Lenartz D, Herold-Mende C, Hartmann C, Mawrin C, Giese N, Eils R, Collins VP, König R, Wiestler OD, Pfister SM, von Deimling A.Acta Neuropathol. 2013 Mar;125(3):351-8. doi: 10.1007/s00401-013-1093-x. Epub 2013 Feb 12.
9. Molecular analysis of alterations of the p18INK4c gene in human meningiomas.
   Santarius T, Kirsch M, Nikas DC, Imitola J, Black PM.Neuropathol Appl Neurobiol. 2000 Feb;26(1):67-75. doi: 10.1046/j.1365-2990.2000.00219.x.

Bibliography

1. Life After a Rare Brain Tumour and Supplementary Motor Area Syndrome: Awake Behind Closed Eyes. Alex Jelly, Adel Helmy, Barbara Wilson, Taylor and Routledge

2. Oxford Textbook of Neurological Surgery. Oxford University Press